Strengths
- 9G-Tronic auto
- PHEV S 500 e
- Best-in-class refinement
Weaknesses
- Heavy
- Cabin dated vs W223
- Premium running costs
Notable tech
- MRA platform
- 9G-Tronic auto from 2014
- M276 V6 / M278 V8 / M157 AMG TT V8 / M279 V12
- S 500 e PHEV
- AirMatic
- Magic Body Control
Common issues
- 9G-Tronic software
- PHEV charging port
- MBUX freezes pre-2018
- AirMatic
Engine derivatives
UK trims and engines offered across W222's life. Click any two rows to compare them side-by-side.
Pick two engines to compare
S 350 d V6
BHP282
Torque600 Nm
0–606.0 s
Top155 mph
MPG46 mpg
DriveRWD / 4MATIC
Gearbox9AT
S 400 4MATIC V6
BHP333
Torque480 Nm
0–605.2 s
Top155 mph
MPG32 mpg
DriveAWD
Gearbox9AT
S 500 V8
BHP449
Torque700 Nm
0–604.8 s
Top155 mph
MPG32 mpg
DriveRWD / 4MATIC
Gearbox9AT
S 500 e PHEV
BHP436
Torque650 Nm
0–605.2 s
Top155 mph
Range~20 mi EV
DriveRWD
Gearbox7AT
S 600 V12 BiTurbo
BHP522
Torque830 Nm
0–604.6 s
Top155 mph
MPG20 mpg
DriveRWD
Gearbox7AT
S 63 AMG 4MATIC+
BHP603
Torque900 Nm
0–603.5 s
Top186 mph
MPG28 mpg
DriveAWD
Gearbox9AT
S 65 AMG V12
BHP621
Torque1,000 Nm
0–604.3 s
Top186 mph
MPG20 mpg
DriveRWD
Gearbox7AT